Genetic Testing For Mast Cell Disorders

One of the hallmarks of an allergic process includes mast cell activation and subsequent release of mediators – the most abundant of which is tryptase. Elevated tryptase in the absence of provocation or exposure to an allergen(s) may be indicative of systemic mastocytosis, hereditary alpha-tryptasemia, or other mast cell disorders. Although each disorder presents with similar, recurrent allergy-like symptoms, sometimes severe, the underlying disease process may be vastly different, which can make targeted therapy difficult to achieve. Our highly sensitive genetic tests for mast cell disorders provide results that can assist in the differential diagnosis of these disorders and increase the efficiency and confidence of clinical action.