Genetic Testing Solutions
The Virant Diagnostics Genetic Laboratory uses cutting-edge science and technology to provide accurate genomic testing.
About Our Genetic Laboratory
The Virant Diagnostics Genetic Laboratory is made up a team of experienced geneticists and molecular biologists. Our specialized knowledge and advanced laboratory equipment allows us to provide the highest quality molecular diagnostic services. We use a proprietary bioinformatics pipeline with the most up-to-date and relevant data to analyze your samples. Virant Diagnostics is ready to work with your team to improve patient care.
Create an order and view results now.
- Create an order from our Client Portal or via Requisition Form
- Please be sure to obtain patient consent for genetic testing
- Access secure, encrypted results from our Client Portal
Our Genetic Test Menu
Individual Gene Testing
- SERPING1 Sequencing of the coding region +/- 10 base pairs for exons 2-8 with exon duplication/deletion testing
| Gene | OMIM | Exon(s) | |
|---|---|---|---|
| C1INH gene | Region | ||
| SERPING1 | 106100 | 2-8 | Coding +/- 10 bp |
- Sequencing of known mutations in 6 OMIM related angioedema genes (see list below)
- We also offer duplication/deletion testing for F12 gene, exons 1-12, except exon 3
| Gene | OMIM | Exon(s) | ||
|---|---|---|---|---|
| nlC1INH gene | Screen for known HAE variant(s) | |||
| F12 gene | 610618 | 9 | c.983C>A c.983C>G | p.Thr328Lys p.Thr328Arg |
| KNG1 gene | 619363 | 10 | c.1136T>A c.1720C>G | p.Met379Lys p.Pro574Ala |
| ANGPT1 gene | 619361 | 2 | c.807G>T | p.Ala119Ser |
| PLG gene | 619360 | 9, 18 | c.988A>G c.2183T>A | p.Lys330Glu p.Val728Glu |
| MYOF gene | 619366 | 7, 25 | c.651G>T c.2576delG | p.Arg217Ser p.Gly859Glufs*8 |
| HS3ST6 gene | 619367 | 2 | c.430A>T | p.Thr144Ser |
- Targeted testing for a SERPING1 coding variant, or variants listed in the nlC1INH table above previously identified in a family member
- Clinical confirmation of variants found in a research laboratory
Small Panel Testing
- All known HAE variants in the 6 genes associated with angioedema with normal C1 inhibitor function
- Genes tested:
- F12, KNG1, ANGPT1, PLG, MYOF, HS3ST6
- All 7 genes (SERPING1 and nlC1INH genes)
- Genes tested:
- SERPING1, F12, KNG1, ANGPT1, PLG, MYOF, HS3ST6
Large Panel Testing
- This gene panel sequences and analyzes 77 genes involved with complement, coagulation, and tissue kallikrein pathways
- Click here for details and descriptions for each gene on the panel
Whole Exome Sequencing
- Whole exome sequencing sequences in all protein-coding regions of the genome. Analysis reviews all identified variants along with relevant medical history to reveal diseases that a patient may have, develop, and/or pass down
- Must provide clinical information when submitting a sample
- Maternal and paternal samples in addition to proband samples are helpful
Click here for references.
