Genetic Testing Solutions

The Virant Diagnostics Genetic Laboratory uses cutting-edge science and technology to provide accurate genomic testing.

About Our Genetic Laboratory

The Virant Diagnostics Genetic Laboratory is made up a team of experienced geneticists and molecular biologists. Our specialized knowledge and advanced laboratory equipment allows us to provide the highest quality molecular diagnostic services. We use a proprietary bioinformatics pipeline with the most up-to-date and relevant data to analyze your samples. Virant Diagnostics is ready to work with your team to improve patient care.

Create an order and view results now.

Our Genetic Test Menu

Individual Gene Testing

  • SERPING1 Sequencing of the coding region +/- 10 base pairs for exons 2-8 with exon duplication/deletion testing
Gene OMIM Exon(s)
C1INH gene Region
SERPING1 106100 2-8 Coding +/- 10 bp
  • Sequencing of known mutations in 6 OMIM related angioedema genes (see list below)
  • We also offer duplication/deletion testing for F12 gene, exons 1-12, except exon 3
Gene OMIM Exon(s)
nlC1INH gene Screen for known HAE variant(s)
F12 gene 610618 9 c.983C>A c.983C>G p.Thr328Lys p.Thr328Arg
KNG1 gene 619363 10 c.1136T>A c.1720C>G p.Met379Lys p.Pro574Ala
ANGPT1 gene 619361 2 c.807G>T p.Ala119Ser
PLG gene 619360 9, 18 c.988A>G c.2183T>A p.Lys330Glu p.Val728Glu
MYOF gene 619366 7, 25 c.651G>T c.2576delG p.Arg217Ser p.Gly859Glufs*8
HS3ST6 gene 619367 2 c.430A>T p.Thr144Ser
  • Targeted testing for a SERPING1 coding variant, or variants listed in the nlC1INH table above previously identified in a family member
  • Clinical confirmation of variants found in a research laboratory

Small Panel Testing

  • All known HAE variants in the 6 genes associated with angioedema with normal C1 inhibitor function
  • Genes tested:
    • F12, KNG1, ANGPT1, PLG, MYOF, HS3ST6
  • All 7 genes (SERPING1 and nlC1INH genes)
  • Genes tested:

Large Panel Testing

  • This gene panel sequences and analyzes 77 genes involved with complement, coagulation, and tissue kallikrein pathways
  • Click here for details and descriptions for each gene on the panel

Whole Exome Sequencing

  • Whole exome sequencing sequences in all protein-coding regions of the genome. Analysis reviews all identified variants along with relevant medical history to reveal diseases that a patient may have, develop, and/or pass down
  • Must provide clinical information when submitting a sample
  • Maternal and paternal samples in addition to proband samples are helpful

Click here for references.