Angioedema Testing Solutions
Angioedema is a self-limited, transient, and localized swelling caused by extravascular leakage of fluid into the interstitial tissues commonly involving the subcutaneous and/or the submucosal tissues of the skin and upper respiratory and gastrointestinal tracts, respectively. Angioedema attacks can be acute, lasting hours to days, or chronic if recurrent. Symptoms may be troublesome, disabling, and even life-threatening. The swelling in angioedema is caused by increased vascular permeability, which is mediated by histamine or bradykinin. Bradykinin-mediated angioedema is not triggered by allergies, therefore treatment with antihistamines and steroids are ineffective.
Hereditary angioedema (HAE) is a rare inherited prototype of bradykinin-mediated angioedema. In contrast to acquired angioedema, which is a secondary process, HAE is associated with genetic variations that result in complement 1 esterase inhibitor (C1-INH) deficiency or dysfunction. Lack of this regulating protein’s action leads to bradykinin accumulation that can drive angioedema attacks in various anatomic areas. Diagnosis relies on clinical and family history, C1INH functional levels, C4 complement tests, and genetic testing.
Contact System Pathway
Create an order and access test results.
- Create an order from Our Client Portal or via Requisition Form
- Please be sure to obtain patient consent for genetic testing
- Access secure, encrypted results from our Client Portal
Our Angioedema Test Menu
Angioedema Complement Assays & Genetic Testing
For more information on Angioedema: